Raj K Puri Selected Research

IL13-PE38

8/2010	Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma.
1/2010	Therapeutic efficacy of Cintredekin Besudotox (IL13-PE38QQR) in murine lung fibrosis is unaffected by immunity to Pseudomonas aeruginosa exotoxin A.
3/2009	IL-13 cytotoxin has potent antitumor activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma.
11/2007	Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results.
3/2007	Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.
3/2007	Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group.
2/2007	Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.
8/2006	Intratumoral therapy with IL13-PE38 results in effective CTL-mediated suppression of IL-13Ralpha2-expressing contralateral tumors.
4/2006	Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies.
5/2005	Gene expression profiling identifies IL-13 receptor alpha 2 chain as a therapeutic target in prostate tumor cells overexpressing adrenomedullin.

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Raj K Puri Research Topics

Disease

89	Neoplasms (Cancer) 01/2022 - 01/2002
26	Glioma (Gliomas) 06/2021 - 10/2002
17	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 01/2002
11	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 07/2002
11	Brain Neoplasms (Brain Tumor) 03/2009 - 01/2002
10	Squamous Cell Carcinoma of Head and Neck 03/2014 - 01/2002
7	Breast Neoplasms (Breast Cancer) 01/2022 - 05/2003
7	Neoplasm Metastasis (Metastasis) 01/2021 - 09/2005
6	Head and Neck Neoplasms (Head and Neck Cancer) 02/2013 - 02/2002
5	Fibrosis (Cirrhosis) 11/2013 - 01/2006
4	Adenocarcinoma 05/2020 - 10/2007
4	Ovarian Neoplasms (Ovarian Cancer) 01/2019 - 09/2005
4	Carcinoma (Carcinomatosis) 12/2014 - 03/2003
4	Melanoma (Melanoma, Malignant) 07/2012 - 04/2006
4	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2010 - 05/2003
3	Adrenocortical Carcinoma 01/2022 - 07/2015
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 11/2002
3	Lung Neoplasms (Lung Cancer) 01/2019 - 11/2002
3	Inflammation (Inflammations) 01/2017 - 06/2008
3	Prostatic Neoplasms (Prostate Cancer) 03/2015 - 03/2003
3	Granuloma 11/2013 - 10/2002
3	Infections 11/2013 - 08/2005
3	Necrosis 08/2009 - 08/2003
3	Kaposi Sarcoma (Kaposi's Sarcoma) 01/2006 - 01/2002
3	Asthma (Bronchial Asthma) 01/2006 - 06/2002
3	Idiopathic Interstitial Pneumonias 06/2004 - 09/2003
3	Idiopathic Pulmonary Fibrosis 06/2004 - 09/2003
2	Astrocytoma (Pilocytic Astrocytoma) 12/2018 - 10/2003
2	Urinary Bladder Neoplasms (Bladder Cancer) 03/2015 - 12/2014
2	Lymphatic Metastasis 07/2012 - 05/2005
2	Carcinogenesis 01/2012 - 06/2007
2	Sarcoma (Soft Tissue Sarcoma) 11/2011 - 11/2010
2	Hodgkin Disease (Hodgkin's Disease) 11/2006 - 05/2005
2	Hypersensitivity (Allergy) 01/2006 - 05/2004
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2006 - 08/2004
2	Renal Cell Carcinoma (Grawitz Tumor) 08/2004 - 01/2002
1	Colorectal Neoplasms (Colorectal Cancer) 01/2022
1	Testicular Neoplasms (Testicular Cancer) 06/2021
1	Adrenal Cortex Neoplasms (Adrenocortical Cancer) 06/2021

Drug/Important Bio-Agent (IBA)

58	Interleukin-13IBA 01/2022 - 02/2002
49	Cytotoxins (Cytolysins)IBA 11/2011 - 01/2002
38	ExotoxinsIBA 01/2019 - 02/2002
32	Interleukin-13 Receptors (Interleukin 13 Receptor)IBA 01/2022 - 02/2002
27	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2002
24	Interleukin-4 (Interleukin 4)IBA 01/2019 - 01/2002
16	Immunotoxins (Immunotoxin)IBA 09/2015 - 05/2003
14	Interleukin-4 Receptors (Interleukin 4 Receptor)IBA 11/2015 - 01/2002
14	IL13-PE38IBA 08/2010 - 02/2002
13	CytokinesIBA 01/2022 - 06/2002
13	Pharmaceutical PreparationsIBA 08/2014 - 01/2002
11	Biomarkers (Surrogate Marker)IBA 06/2021 - 10/2002
11	Interleukin-13 Receptor alpha2 SubunitIBA 05/2020 - 10/2002
10	InterleukinsIBA 11/2006 - 06/2002
9	AntigensIBA 01/2022 - 08/2003
9	Messenger RNA (mRNA)IBA 01/2019 - 03/2003
6	Pseudomonas aeruginosa Exotoxin AIBA 01/2010 - 10/2003
5	LigandsIBA 06/2021 - 02/2003
5	Peptides (Polypeptides)IBA 06/2021 - 02/2003
5	InterferonsIBA 01/2019 - 08/2002
5	Cell Surface ReceptorsIBA 04/2012 - 10/2003
5	interleukin-4-Pseudomonas exotoxinIBA 07/2005 - 07/2002
4	Cytokine Receptors (Cytokine Receptor)IBA 09/2015 - 08/2002
4	Complementary DNA (cDNA)IBA 01/2015 - 10/2003
4	Cancer VaccinesIBA 01/2014 - 07/2009
4	Neoplasm Antigens (Tumor Antigens)IBA 02/2013 - 11/2008
4	Recombinant Fusion ProteinsIBA 08/2004 - 05/2003
3	Carrier Proteins (Binding Protein)IBA 06/2021 - 08/2002
3	EnzymesIBA 01/2019 - 10/2008
3	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 12/2018 - 11/2009
3	Biological ProductsIBA 09/2015 - 02/2005
3	CollagenIBA 03/2014 - 10/2002
3	Matrix Metalloproteinases (MMPs)IBA 07/2012 - 11/2009
3	DNA VaccinesIBA 11/2011 - 04/2006
3	DNA (Deoxyribonucleic Acid)IBA 11/2011 - 02/2002
3	VaccinesIBA 11/2010 - 09/2008
3	Interleukin-13 Receptor alpha1 SubunitIBA 01/2006 - 12/2003
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2004 - 10/2002
2	Hormones (Hormone)IBA 01/2021 - 11/2008
2	Transcription Factors (Transcription Factor)IBA 12/2018 - 05/2008
2	Gemcitabine FDA Link 03/2011 - 10/2007
2	poliferprosan 20 drug combination carmustine (Gliadel)FDA Link 08/2010 - 04/2006
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 01/2010 - 01/2006
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2010 - 09/2003
2	AdrenomedullinIBA 11/2008 - 05/2005
2	RNA (Ribonucleic Acid)IBA 06/2008 - 06/2005
2	Human Serum Albumin FDA LinkGeneric 03/2007 - 02/2007
2	Therapeutic UsesIBA 08/2004 - 09/2003
2	SteroidsIBA 01/2004 - 09/2003
2	Caspase 3 (Caspase-3)IBA 01/2003 - 10/2002
1	Pyruvate KinaseIBA 01/2019
1	Glucose (Dextrose)FDA LinkGeneric 01/2019
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2019
1	Sodium Glutamate (Accent)IBA 12/2015

Therapy/Procedure

56	Therapeutics 01/2022 - 01/2002
10	Immunotherapy 01/2022 - 02/2002
6	Catheters 08/2010 - 02/2005
3	Injections 12/2004 - 07/2002
2	Intranasal Administration 01/2010 - 09/2003
2	Radiotherapy 11/2007 - 10/2003
2	Aftercare (After-Treatment) 10/2002 - 02/2002